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GcMAF Science

GcMAF Enhances Fc-receptor Mediated Rosette Formation but Hardly Affects Superoxide Production in Human Monocytes.

GcMAF has been reported as a potent macrophage activating factor derived from serum Gc protein (Gc globulin). We compared the effects of GcMAF with those of IFN-.GAMMA. on the morphology, superoxide production and Fc-receptor mediated rosette formation of human monocytes from peripheral blood.

As a result, monocytes stimulated by GcMAF showed hardly any effects on morphological changes and superoxide production, but enhanced Fc-receptor mediated rosette formation. On the other hand, treatment of monocytes with IFN-.GAMMA. increased adherent cells and induced morphological changes.

Therefore, superoxide production per cell protein of adherent monocytes treatment with IFN-.GAMMA. was significantly decreased, and slight effects were observed on Fc-receptor mediated rosette formation. These results indicate that effects of GcMAF on human monocytes were different from those of IFN-.GAMMA.

Accession number;02A0214753

Title;GcMAF Enhances Fc-receptor Mediated Rosette Formation but Hardly Affects Superoxide Production in Human Monocytes.

Author;OYAMA YUJIRO(Hayashibaraseibutsukagakuken Kankoshikisoken) NAKAGAWA YOSHINORI(Hayashibaraseibutsukagakuken Kankoshikisoken) HORI HITOSHI(Univ. of Tokushima, Fac. of Eng.) NAMBA MASAYOSHI(Okayamadai I Saibouseibutsugaku)

Journal Title;Biotherapy (Tokyo)

Journal Code:L0028A

ISSN:0914-2223

VOL.16;NO.1;PAGE.79-85(2002)

Figure&Table&Reference;FIG.2, TBL.2, REF.14

Pub. Country;Japan

Language;Japanese

Source: http://sciencelinks.jp/j-east/article/200207/000020020702A0214753.php